Are you having trouble falling asleep or staying asleep at night? Research from the University of Colorado School of Medicine suggests taking Cannabidiol before bed improves the sleep quality of people with insomnia.
The United States Food and Drug Administration (FDA) has not approved CBD for the treatment of any condition. It can be difficult to know whether a product contains a safe or effective level of CBD or whether the product has the properties and contents stated on its packaging and marketing.
The clinical use of THC is often limited by its unwanted psychoactive side effects, and for this reason interest in non-psychoactive phytocannabinoids, such as CBD, has substantially increased in recent years. In fact, CBD is being used to reduce the intoxicating effects of THC, such as paranoia and memory impairment. (19)
Rigorous clinical studies are still needed to evaluate the clinical potential of CBD for specific conditions.i However, pre-clinical research (including both cell culture and animal models) has shown CBD to have a range of effects that may be therapeutically useful, including anti-seizure, antioxidant, neuroprotective, anti-inflammatory, analgesic, anti-tumor, anti-psychotic, and anti-anxiety properties.
Worse, CBD is being produced without any regulation, resulting in products that vary widely in quality, said Marcel Bonn-Miller, an adjunct assistant professor of psychology in psychiatry at the University of Pennsylvania School of Medicine.
On Mar. 20, 2017, Gov. Bryant approved SB 2610, which amended the state’s CBD law to “clarify use in research of seizures and other medical conditions.” The bill allows other pharmacies to dispense CBD in addition to the University of Mississippi Medical Center, with federal and state regulatory approval.
The NIH recognizes the need for additional research on the therapeutic effects of CBD and other cannabinoids, and supports ongoing efforts to reduce barriers to research in this area. NIH is currently supporting a number of studies on the therapeutic effects as well as the health risks of cannabinoids. These include studies of the therapeutic value of CBD for:
Granjeiro EM, Gomes FV, Guimaraes FS, et al. Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress. Pharmacol Biochem Behav 2011;99(4):743-8. View abstract.
Bhattacharyya S, Fusar-Poli P, Borgwardt S, et al. Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis. Arch Gen Psychiatry 2009;66(4):442-51. View abstract.
Much more research is needed, he says, to establish whether CBD works, and if so for what conditions, but he understands that severely ill patients, or their parents, may not want to wait for this data: “If other drugs don’t work, it’s certainly reasonable to try this.”
As explained earlier, CBD has potent anti-inflammatory effects. And thanks to this CBD may give people arthritis relief and joint pain relief. Cannabidiol does this by reducing pain, swelling and you may see reduced joint destruction, along with slower disease progression of your arthritis. In one animal study, CBD was able to protect joints from severe damage and showed an improvement in arthritis symptoms. Another controlled study ran for five weeks and showed excellent improvements in lowering pain, improving sleep quality and inflammation.
Zuardi, A. W., Shirakawa, I., Finkelfarb, E., and Karniol, I. G. Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. Psychopharmacology (Berl) 1982;76(3):245-250. View abstract.
Different states also require different levels of prescription to possess and use CBD oil. In Missouri, for example, a person must show that three other treatment options have been unsuccessful in treating epilepsy.
“CBD has been a game-changer for medical marijuana,” says Martin Lee, the director of Project CBD, a Northern California nonprofit that promotes use of the compound. “Its safety and lack of psychoactivity undermines any argument that it should be illegal. It’s really shifted the national discussion on this issue.”
In 2011, researchers added light on the cellular mechanism through which CBD induces cell death in breast cancer cells. They showed that CBD induced a concentration-dependent cell death of both oestrogen receptor-positive and oestrogen receptor-negative breast cancer cells. They also found that the effective concentrations of CBD in tumor cells have little effect on non-tumorigenic, mammary cells. (11)
A small medical research study took a small group (24 people) who suffer from social anxiety and gave them 600mg of Cannabidiol or placebo. The study wanted to see if CBD has any effect on people with a fear of public speaking. The Cannabidiol group performed significantly better than the placebo group. The CBD group had less anxiety and less cognitive impairment. Also, the CBD group was happier. Cannabidiol has also shown great promise helping children with PTSD. And it has also been said CBD has almost antidepressant qualities.
Although the World Health Organization listed Cannabidiolum in a list of International Nonproprietary Names for Pharmaceutical Substances (INN) on 30 June 2016. French and Spanish versions wrongly mention agonist action of CBD on cannabinoid receptors while the English version says CBD is a cannabinoid receptor antagonist.
Zuardi, A. W., Crippa, J. A., Hallak, J. E., Bhattacharyya, S., Atakan, Z., … & Guimarães, F. S. (2012). A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation [Abstract]. Current Pharmaceutical Design, 18(32), 5,131-5,140. Retrieved from www.ncbi.nlm.nih.gov/pubmed/22716160
Jump up ^ Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S (June 2007). “Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa”. FEBS Letters. 581 (16): 2929–34. doi:10.1016/j.febslet.2007.05.043. PMID 17544411.
I don’t have a website for you (sorry) but with google, they have all kinds of natural pet cbds that are safe for our furry friends. I’ve read regular cbd that us 2-legged animals use are not the safest for them 🙂 best of luck!
I was reading Tina’s review casually when I SAW MYSELF! Low to little or at times no energy. Constant pain in joints, knee pain – bone to bone. Shoulders busted – torn rotators. Head, neck & shoulder injuries – all from military & LE as Motorcycle Officer. DAV & Disabled cop, went down in ‘98.
I have been using a nano-enhanced Hemp oil for my chronic arthritis and it’s helped tremendously! I’ve had 3 hip replacements within a 14 month period and still have pain. I also suffer from chronic back pain from a fall some years ago (or rather, slid down on my butt) down stairs. After the first day of taking it I woke up the next morning NOT needing a pain pill as I normally do just to get out of bed. I felt amazing!! I try to take it regularly (I can’t stand the taste) because I know it works. I say, if Hemp oil works it’s a good brand, if it doesn’t, either try another or move on to CBD oil.
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But studying CBD is not easy: Scientists complain that laws and regulations put excessive constraints on their work. Although it doesn’t make users high, CBD (both the molecule and CBD-rich cannabis) is classified by the federal government as a Schedule 1 drug, which means they have high potential for abuse and no accepted medical use.
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