FDA DISCLOSURE: These statements have not been evaluated by the FDA and are not intended to diagnose, treat, or cure any disease. Always check with your physician before starting a new dietary supplement program.
Third party laboratories analyze all of our full-spectrum hemp extracts and supplements for cannabinoid potency, heavy metals, bacterial/microbial life, mycotoxins (fungus), and pesticides. Our isolate is tested for potency, heavy metals, and pesticides. The unsummarized results of testing for all produced batches can be found in our online batch database.
CBD comes from Cannabis sativa L, an annual herbaceous flowering plant. Cannabis sativa L. is the plant species, and does not mean our products will have the sativa like effects typically associated with those strains of marijuana. The indica and sativa distinction does not have as much bearing on the plant’s effects without the presence of THC. Cannabis Sativa, Cannabis Indica, and Cannabis Ruderalis are all subspecies of Cannabis Sativa L. Our hemp extract is made with cultivars that are bred with approximately 70% sativa and 30% indica genetics.
Valenti M, Massi P, Bolognini D, et al. Cannabidiol, a non-psychoactive cannabinoid compound inhibits human glioma cell migration and invasiveness. 34th National Congress of the Italian Society of Pharmacology 2009.
^ Jump up to: a b Scuderi C, Filippis DD, Iuvone T, Blasio A, Steardo A, Esposito G (May 2009). “Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders”. Phytotherapy Research (Review). 23 (5): 597–602. doi:10.1002/ptr.2625. PMID 18844286.
The cost of treatment varies: Depending on the dispensary and the dosage, it can range from around $100 a month to more than $1,000. Despite the cost, which is not covered by insurance, CBD medicines are drawing great interest for children with severe, intractable epilepsy. California and Colorado, which were among the first states to legalize medical marijuana, have become hot spots for such patients. Before other states legalized medicinal CBD use, some families moved to these states so they could have access to the compound.
In addition to CBD, Cannabis sativa L contains organic compounds called terpenes. Terpenes are isomeric hydrocarbons (C10H16) used to create essential oils, balsams, and other by-products. When chemically modified through oxidation or other methods, terpenes become terpenoids (sometimes referred to as isoprenoids). Vitamin A is one example of a terpenoid.
Research suggests that CBD may exert some of its pharmacological action through its inhibition of fatty acid amide hydrolase (FAAH), which may in turn increase the levels of endocannabinoids, such as anandamide, produced by the body. It has also been speculated that some of the metabolites of CBD have pharmacological effects that contribute to the biological activity of CBD.
Devinsky, O., Cilio, M. R., Cross, H., Fernandez-Ruiz, J., French, J., Hill, C., … & Friedman, D. (2014, June). Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia, 55(6), 791-802. Retrieved from www.ncbi.nlm.nih.gov/pmc/articles/PMC4707667/
CBD (Cannabidiol) is a prominent, non-psychoactive cannabinoid found in hemp. It is generally extracted from hemp plants that are naturally high in CBD and other phytochemicals. There are over 80 different cannabinoids found in hemp. It is commonly used for its therapeutic properties.
From what we understand Cannabinoids seem to tap into the ECS and produce extremely positive effects. CBD has this positive because it can interact with cells in our body because the CBD molecule is akin to a chemical the body produces naturally called endocannabinoids.
CBD Oil Lehigh Acres FL | CBD Legal To Buy Near Me
About CBD Oil Lehigh Acres FL | CBD Legal To Buy In August, 2017
Definitely not. Standard hemp oil, which can be found very cheaply at a grocery store, is a much different product than our full spectrum hemp extracts (not from seed). Standard hemp oil is produced by cold pressing the seeds, whereas our hemp extract is a full plant extraction with many components not typically found in the seeds. Hemp seed oil is considered to be a great nutritive food, but it doesn’t have the naturally occurring terpenes, cannabinoids and other components that our extracts do have.
Jump up ^ Prud’homme M, Cata R, Jutras-Aswad D (2015). “Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence”. Substance Abuse. 9: 33–8. doi:10.4137/SART.S25081. PMC 4444130 . PMID 26056464.
NIDA is currently collaborating with the National Institute on Neurological Disorders and Stroke to evaluate CBD in animal models of epilepsy in order to understand the underlying mechanisms and optimize the conditions under which CBD may treat seizure disorders, and determine whether it works synergistically with other anti-seizure medications. In addition, clinical trials are currently underway by GW Pharmaceuticals, testing the efficacy of Epidiolex, a purified CBD extract, for treatment of pediatric epilepsy.
There are no cannabinoids, such as THC or CBD, present in hemp oil as the seeds are not psychoactive. Hemp oil is legal in most countries and found in food markets, together with more common types of oil, such as olive or coconut.
It used to be thought that CBD acts on these CB2 receptors, but it appears now that CBD does not act on either receptor directly. Instead, it seems to influence the body to use more of its own cannabinoids.
They also charged my credit card within 5 minutes of the order. If I hadn’t Already paid I wouldn’t really care. But charging me then a week later nothing…. and seeing a lot of recent reviews with the same issue- not a good look pure kana!!
CBD does not appear to have any psychoactive (“high”) effects such as those caused by ∆9-THC in marijuana, but may have anti-anxiety and anti-psychotic effects. As the legal landscape and understanding about the differences in medical cannabinoids unfolds, it will be increasingly important to distinguish “medical marijuana” (with noted varying degrees of psychotropic effects and deficits in executive function) – from “medical CBD”.
Some studies show that CBD can counteract these adverse effects, but more research is needed, as most of this research is done on animals or is based on anecdotal reports. Little research has focused on the safety and side effects of CBD in humans; however, clinical trials indicate that only a few, generally mild side effects have been observed after CBD administration and tolerance for CBD does not seem to occur.
Cannabidiol is currently a class B1 controlled drug in New Zealand under the Misuse of Drugs Act. It is also a prescription medicine under the Medicines Act. In 2017 the rules were changed so that anyone wanting to use it could go to the Health Ministry for approval. Prior to this, the only way to obtain a prescription was to seek the personal approval of the Minister of Health.
On July 14, 2014, Missouri Governor Jay Nixon signed HB 2238 into law, which allows the use of cannabis oil that is at least 5% CBD and less than 0.3% THC for intractable epilepsy. The bill requires a neurologist to determine that the patient did not respond to at least three treatment options to be eligible to use the marijuana extract.
Our hemp extracts may be extremely low in THC, but they are rich in terpenes. Terpenes are organic compounds and isomeric hydrocarbons (C10H16) found within hemp flower excretions. At Bluebird Botanicals, we develop the genetics for our hemp in highly-specialized Colorado greenhouses and source our crops from outdoor farms, which use organic growing methods and no pesticides. These farms cultivate specialty high-terpene hemp plants specifically bred to for the production of hemp and CBD oil.
In three full-bodied flavors, these pop-and-go replacement cartridges for the Alternate Vape BudTouch e-pen are made with high-quality, all-natural ingredients and contain no nicotine and virtually no THC.
Cannabidiol (CBD) is a naturally occurring cannabinoid constituent of cannabis. It was discovered in 1940 and initially thought to not be pharmaceutically active. It is one of at least 113 cannabinoids identified in hemp plants, accounting for up to 40% of the plant’s extract.
Furthermore, our partnering farms grow hemp plant strains that contain higher terpene content than other hemp plants. While marijuana plants indeed contain relatively high amounts of terpene-rich resin, the hemp plants we use are equally endowed.
No. Many people are under the impression that the only way to acquire hemp extracts and CBD for themselves or a loved one is to move to Colorado or another cannabis-friendly state. Many major news outlets are misinformed and are unfortunately spreading the idea that you can only get CBD oil in the states where medical marijuana has been legalized. This is simply not the case though. Because our extracts come from hemp instead of marijuana, we can and do ship nationwide, and no medical marijuana card is needed. There are some exceptions, like with South Dakota, where we can’t sell our products due to state legislation.
Collin, C., Davies, P., Mutiboko, I. K., and Ratcliffe, S. Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis. Eur.J.Neurol. 2007;14(3):290-296. View abstract.
At Harmony, we are always happy to answer any questions and ensure that our valued clientele can purchase products that are right for their individual needs. Contact us if you wish to receive our certificate of analysis!
On May 4, 2016, Gov. Bentley signed HB 61 into law. Known as Leni’s Law, the bill provides an affirmative defense for possession of CBD oil “for specified debilitating conditions that produce seizures.”
Ligresti A, Moriello AS, Starowicz K, et al. Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther 2006;318(3):1375-87. View abstract.
Cannabidiol, also known as CBD, is one of over 60+ naturally occurring cannabinoid compounds found in Cannabis, an annual herbaceous flowering plant. CBD oil is derived from an organic substance formed in the plant’s secretions. Both marijuana and hemp are forms of cannabis. However, cannabis does not mean marijuana. Cannabis is the genus name and general umbrella term, under which all forms of marijuana and hemp fall. Until recently, delta-9 tetrahydrocannabinol, or THC, was the most well-known and studied cannabinoid due to its abundance in marijuana. However, as the second most prevalent cannabinoid in marijuana and the top non-psychoactive cannabinoid found in hemp, CBD has been gaining momentum in the scientific community and media.
There have been multiple clinical trials demonstrating the efficacy of nabiximols on central and peripheral neuropathic pain, rheumatoid arthritis, and cancer pain.xxiii In addition, nabiximols is currently approved in Canada for the treatment of central neuropathic pain in MS and cancer pain unresponsive to opioid therapy. However, the current evidence suggests that the analgesia is mediated by THC and it is unclear whether CBD contributes to the therapeutic effects.xxiv THC alone has been shown to reduce pain;xxv,xxvi we are unaware of clinical studies that have explored the efficacy of CBD alone on pain. However, the anti-inflammatory properties of CBD (discussed above) could be predicted to play a role in the analgesic effects of nabiximols. Recent research has also suggested that cannabinoids and opioids have different mechanisms for reducing pain and that their effects may be additive, which suggests that combination therapies may be developed that may have reduced risks compared to current opioid therapies. However, this work is very preliminary.xxvii
There is preclinical (rodent) evidence to suggest that cannabidiol may reduce THC clearance, modestly increasing THC’s plasma concentrations resulting in a greater amount of THC available to receptors, increasing the effect of THC in a dose-dependent manner. A small clinical trial reported that CBD partially inhibits the CYP2C catalyzed hydroxylation of THC to 11-OH-THC.
^ Jump up to: a b c d Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M (July 2017). “Cannabidiol: State of the art and new challenges for therapeutic applications”. Pharmacol. Ther. 175: 133–150. doi:10.1016/j.pharmthera.2017.02.041. PMID 28232276.
“The endocannabinoid system (ECS) is a group of endogenous cannabinoid receptors located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors.” Wikipedia
We use 100% Colorado-grown hemp extracts in our dietary supplement manufacturing. The only exception is the certified organic, Canadian-grown hemp seed oil that is still used as the base oil in our Classic formulations.
Jump up ^ Ujváry I, Hanuš L (2014). “Human Metabolites of Cannabidiol: A Review on Their Formation, Biological Activity, and Relevance in Therapy”. Cannabis and Cannabinoid Research. 1 (1): 90–101. doi:10.1089/can.2015.0012. PMC 5576600 . PMID 28861484.
Over the past decade and especially in recent years the medical field has invested a lot of time and resources into the study of CBD with some astounding results being discovered. Though it must be stated there is still much to uncover about the safety and efficacy of CBD products. But recent results from several studies from well respected medical institutions are suggesting CBD may help improve the quality of life for many people through providing a safe, powerful and natural treatment for many different health conditions.
Jump up ^ Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E (February 2006). “Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors”. Naunyn-Schmiedeberg’s Archives of Pharmacology. 372 (5): 354–61. doi:10.1007/s00210-006-0033-x. PMID 16489449.
After discussing dosage and risks with a doctor, and researching regional legal use, it is important to compare different brands. There are a range of different CBD oils available to purchase online, with different benefits and applications.
Some CBD oil products can be mixed into different foods or drinks, taken from a pipette or dropper, or are available as a thick paste to be massaged into the skin. CBD can also be purchased in capsule form.
Dalterio S, Steger R, Mayfield D, Bartke A. Early cannabinoid exposure influences neuroendocrine and reproductive functions in mice: II. Postnatal effects. Pharmacol Biochem Behav 1984;20(1):115-23. View abstract.
Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. Cannabidiol has shown to reduce anxiety in patients with social anxiety disorder and researchers suggest that it may also be effective for panic disorder, obsessive compulsive disorder, social anxiety disorder and post-traumatic stress disorder. (7)
Disabled Vet, disabled cop, cancer survivor, chronic pain, PTSD, depression,anxiety as well as social anxiety. Those are mere DIAGNOSES, praise God. (GEN 1:29) I went natural two years ago – Stage III – year to live w/o treatment. Started smoking regularly – healed.
“HB105 gives Utahns with epilepsy trial access to a non-intoxicating, seizure-stopping cannabis oil. But it doesn’t take effect until July 1, 2014, and until then, Utahns can’t legally possess cannabis oil.
Because of their active ingredients, it’s possible to experience side effects when taking dietary supplements. The U.S. Department of Health & Human Services maintains that people are most likely to experience negative side effects by combining supplements or by taking them in place of or in addition to prescribed medicines.
The benefits and risks of some supplements on the market are undetermined by federal agencies. These supplements will undergo further study before any definitive claims may be made about their value to the human body. Our hemp extracts fall under this category of supplements. Consumers must be aware that just because a dietary supplement is on the market does not mean it is federally tested and approved. Many dietary supplements, including CBD oil, may be marketed before the FDA has rated their efficacy.
Crippa JA, Derenusson GN, Ferrari TB, et al. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacol 2011;25(1):121-30. View abstract.
Although the World Health Organization listed Cannabidiolum in a list of International Nonproprietary Names for Pharmaceutical Substances (INN) on 30 June 2016. French and Spanish versions wrongly mention agonist action of CBD on cannabinoid receptors while the English version says CBD is a cannabinoid receptor antagonist.
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