Mr. Chairman, Ms. Chairwoman, and Members of the Senate Drug Caucus, thank you for inviting the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health (NIH), to participate in this hearing to share what we know about the biology and the potential therapeutic effects of cannabidiol (CBD), one of the main active chemical compounds found in marijuana. In light of the rapidly evolving interest in the potential use of marijuana and its derivative compounds for medical purposes, it is important to take stock of what we know and do not know about the therapeutic potential of CBD.
According to the North Carolina Department of Health and Human Services (DHHS), “hemp extract must be composed of less than nine-tenths of one percent (0.9%) tetrahydrocannabinol (THC) by weight, at least five percent (5%) cannabidiol (CBD) by weight and may contain no other psychoactive substances.” By law, patients are allowed to use and possess CBD but it remains illegal to cultivate or produce hemp extract in the state. People in possession of the DHHS Caregiver Registration letter are allowed to carry hemp extract outside their homes.
The Missouri Hemp Extract Registration Program issues registration cards patients with a diagnosis of intractable epilepsy who meet the program’s criteria, which allows them to possess and use CBD oil in the state.
I also would like to know which cbd oil you would suggest for chronic pain relief? Also does anyone know if it will affect fibroids in any way. Hemp worx sells what sounds like medicinal cbd oil but the label says hemp seed oil? Can any one tell me if this will work medicinally for pain relief
^ Jump up to: a b Resstel LB, Tavares RF, Lisboa SF, Joca SR, Corrêa FM, Guimarães FS (January 2009). “5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats”. British Journal of Pharmacology. 156 (1): 181–8. doi:10.1111/j.1476-5381.2008.00046.x. PMC 2697769 . PMID 19133999.
Generally speaking, most marijuana producers and sellers (especially on the black market) don’t test for contaminants (metals, pesticides, bacteria, etc.). Rick Simpson Hemp Oil is actually more a method of extraction than it is a specific product. People use the Rick Simpson method with hundreds of different strains of marijuana, so the THC, CBD and other cannabinoid content of the final oil always vary greatly, depending on the cannabis the consumers are acquiring. Usually what’s used for Rick Simpson oil is a strain with an inferior CBD content (and high THC), because that’s what the vast amount of marijuana is nowadays.
Fusar-Poli P, Allen P, Bhattacharyya S, et al. Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. Int J Neuropsychopharmacol 2010;13(4):421-32. View abstract.
In addition to CBD, Cannabis sativa L contains organic compounds called terpenes. Terpenes are isomeric hydrocarbons (C10H16) used to create essential oils, balsams, and other by-products. When chemically modified through oxidation or other methods, terpenes become terpenoids (sometimes referred to as isoprenoids). Vitamin A is one example of a terpenoid.
I am an osteoarthritis sufferer with significant osteophyte growth on my spine which causes me muscle and nerve irritation on a daily basis. I have tried several NSaid medications and unfortunately tend to suffer side effects such as stomach upset and also severe headaches. I have heard so much about the benefits of cbd oil for arthritis pain relief. My reluctance to try it steams from lack of regulations around full content disclosure. I have a long standing family history of mental illness (skizophrenia). I would want to know 100% beyond a shadow of a doubt that what I was getting was TCH free as TCH does exasperate my anxiety disorder and studies do show a correlation between TCH and the onset of psychosis, at least for those who have a genetic predisposition.
Only recently, marijuana and chemically related compounds have come back to being considered of therapeutic value. A prominent compound found in marijuana or cannabis, CBD, or cannabidiol, has shown to treat numerous diseases. Researchers believe that in view of the very low toxicity and the generally benign side effects of CBD, neglecting or denying CBD benefits and its clinical potential is simply unacceptable.
On Mar. 20, 2017, Gov. Bryant approved SB 2610, which amended the state’s CBD law to “clarify use in research of seizures and other medical conditions.” The bill allows other pharmacies to dispense CBD in addition to the University of Mississippi Medical Center, with federal and state regulatory approval.
Cannabidiol is currently a class B1 controlled drug in New Zealand under the Misuse of Drugs Act. It is also a prescription medicine under the Medicines Act. In 2017 the rules were changed so that anyone wanting to use it could go to the Health Ministry for approval. Prior to this, the only way to obtain a prescription was to seek the personal approval of the Minister of Health.
Jump up ^ Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E (February 2006). “Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors”. Naunyn-Schmiedeberg’s Archives of Pharmacology. 372 (5): 354–61. doi:10.1007/s00210-006-0033-x. PMID 16489449.
I live in TN as well…. what do you mean “legal for certain groups”? I was under the impression it was legal across the state. Is it not? There is a place in Woodbury, TN (not sure where you live) that has a state grant to grow & produce different types of hemp & cbd oils. Ypu may want to check it out. I plan to visit there this week myself as I suffer from migraines almost daily. Here’s the site, I put a space in it after the .com so it would post. halfhillfarm.com /2017/05/05/hemp-extract-cbd-now-available-in-woodbury/
My 15 yr old son has Aspergers, and severe social anxiety. He was unable to go to school at all. He was on several prescription drugs, and there was no improvement. Since using this product he’s off all prescription drugs. He’s back in 10th grade, full time, and getting all As. It’s made a tremendous difference. Excellent product! Truly amazing results!
Rajesh M, Mukhopadhyay P, Batkai S, et al. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol 2010;56(25):2115-25. View abstract.
Crippa JA, Derenusson GN, Ferrari TB, et al. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacol 2011;25(1):121-30. View abstract.
Ohlsson, A., Lindgren, J. E., Andersson, S., Agurell, S., Gillespie, H., and Hollister, L. E. Single-dose kinetics of deuterium-labelled cannabidiol in man after smoking and intravenous administration. Biomed.Environ Mass Spectrom. 1986;13(2):77-83. View abstract.
CBD Oil Junction City CA | Best Place To Buy Near Me
About CBD Oil Junction City CA | Best Place To Buy In August, 2017
For reasons discussed previously, despite its molecular similarity to THC, CBD only interacts with cannabinoid receptors weakly at very high doses (100 times that of THC),xl and the alterations in thinking and perception caused by THC are not observed with CBD.iii.iv,v The different pharmacological properties of CBD give it a different safety profile from THC.
The Virginia Board of Pharmacy “is currently implementing a process for issuing pharmaceutical processor permits [for cannabidiol oil]. It is anticipated that a Request for Application (RFA) process will open in the spring of 2018.”
What makes CBD especially appealing is that it doesn’t get the user high. Most recreational marijuana users want this effect, of course, but many patients would rather avoid it. This has allowed CBD to sidestep many of the political, legal and medical concerns that have hindered the spread of medical marijuana.
According to a 2007 meta-analysis conducted in Canada, the combination of CBD and THC buccal spray was found to be effective in treating neuropathic pain in multiple sclerosis, which can be debilitating for 50 to 70 percent of MS patients. (5)
Governor Abbot stated: “There is currently no cure for intractable epilepsy and many patients have had little to no success with currently approved drugs. However, we have seen promising results from CBD oil testing and with the passage of this legislation, there is now hope for thousands of families who deal with the effects of intractable epilepsy every day.”
Cannabigerol: When olivetolic acid and Geranyl pyrophosphate combine in the plants, they produce cannabigerolic acid. Many cannabinoids are made from cannabigerolic acid (CBGA). CBG, one of the phyto-cannabinoids found in our extracts, is essentially the same as CBGA, but in non-acidic form.
High quality CBD oil is made from the flowers of the hemp plant, not the seeds. To get the most CBD and other whole plant cannabinoids out of the plant, the hemp must be harvested while the flowers are still very small, requiring a large quantity of plant material. This is why CBD products are typically more expensive than hemp seed oil and medical marijuana, but contain a greater number of beneficial compounds and have more far reaching positive health benefits.
Yadav V, Bever C Jr, Bowen J, et al. Summary of evidence-based guideline: complementary and alternative medicine in multiple sclerosis: report of the guideline development subcommittee of the American Academy of Neurology. Neurology. 2014;82(12):1083-92. View abstract.
Hemp and marijuana are cousins in the plant world, but marijuana has a much higher THC content than hemp. Hemp oil contains low levels of CBD – typically less than 25 parts per million – while CBD oil can be up to 15% CBD. Because the plants are related, some unscrupulous sellers of hemp oil are trying to market it for its medicinal value, which is negligible.
After reading all of the success stories with CBD I decided to give the natural CBD from Purekana a try. I placed my order on the 8th and it hasn’t been shipped yet. Not a great introduction to the company.
It is important to note that NIDA’s mission is focused on drug abuse; studies related to the therapeutic effects of CBD in other areas would be funded by the Institute or Center responsible for that program area. For example, studies related to epilepsy will likely be funded by the National Institute of Neurological Disorders and Stroke or by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, while studies related to schizophrenia will likely be funded by the National Institute on Mental Health.
CBD interacts with the body through the endogenous cannabinoid system (ECS) or endocannabinoid system. The endocannabinoid system regulates the body’s normal homeostasis, or general state of balance. This can maintain a healthy mood, sleep habit, appetite, and pain response.
On May 4, 2016, Gov. Bentley signed HB 61 into law. Known as Leni’s Law, the bill provides an affirmative defense for possession of CBD oil “for specified debilitating conditions that produce seizures.”
Though research is limited at this time, CBD has been shown to effectively treat symptoms related to epilepsy and Parkinson’s disease. CBD was also shown to reduce the progression of Alzheimer’s disease in test-tube and animal studies.
17 states have approved the use of low THC, high CBD products for medical reasons in limited situations. Each state has specific requirements and conditions that need to be followed in order to use CBD legally, such as patient registry requirements and definitions of products that are allowed.
[redirect url=’https://www.sodohh.com/bump’ sec=”]