The existence of substantial clinical investigations regarding CBD has been made public. For example, two such substantial clinical investigations include GW Pharmaceuticals’ investigations regarding Sativex and Epidiolex”
Hey Pawel, Our products contain CBD but it is important to understand that they are not medicine. They don’t treat or cure any disease, physical ailment or condition. That being said I cannot recommend one way or the other what would be best in this scenario. Good luck on your CBD journey, we wish you all the best!
SOURCES: Marcel Bonn-Miller, Ph.D., adjunct assistant professor, psychology in psychiatry, University of Pennsylvania School of Medicine, Philadelphia; Timothy Welty, Pharm.D., chair, department of clinical sciences, College of Pharmacy and Health Sciences, Drake University, Des Moines, Iowa
For reasons discussed previously, despite its molecular similarity to THC, CBD only interacts with cannabinoid receptors weakly at very high doses (100 times that of THC),xl and the alterations in thinking and perception caused by THC are not observed with CBD.iii.iv,v The different pharmacological properties of CBD give it a different safety profile from THC.
On June 1, 2015, Texas Governor Greg Abbott signed SB 339, which allows the use of cannabis oil that is no more than 0.5% THC and at least 10% CBD for the treatment of intractable epilepsy. The bill requires patients to get approval from two certified specialists.
There are close to four hundred natural compounds in both marijuana and hemp. Understanding the two most prevalent, tetrahydrocannabinol (THC) and cannabidiol (CBD), is the key to understanding the difference between hemp oil and cannabis oil. THC is the cannabinoid responsible for giving a high or ‘stoned’ feeling. CBD, on the other hand, is not psychotropic. Recently it has attracted a lot of attention from researchers, experts, and entrepreneurs.
Best kept refrigerated (can be left out of the fridge, too). Most people swallow 15 drops or more, as desired. The amount of Hemp Classic that people take on a daily basis can vary greatly. It can be taken day or night, preferably after a meal.
Iuvone, T., Esposito, G., Esposito, R., Santamaria, R., Di Rosa, M., and Izzo, A. A. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem. 2004;89(1):134-141. View abstract.
My step son works at a place that sells both oils. We were visiting him and he gave me a bottle of hemp oil to try because I have severe back and leg pain. I had a spinal fusion about 4 years ago and now I’m looking at needing another one. I have literally been in pain at least at a 3 for a 3 years and this stuff works like magic! I can usually push through pain and get the job done but pay for it for days later. I’m sick of pain pills and all the red tape I have to go through to get them, just so I can be doped up and tired…still not functioning. This hemp oil also has me at a fairly stable 2 on the pain scale. Every night before bed. I hope more people find out about these oils, they are so helpful for so many things!
Wade, D. T., Robson, P., House, H., Makela, P., and Aram, J. A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms. Clin.Rehabil. 2003;17(1):21-29. View abstract.
In addition to the research on the use of cannabinoids in palliative treatments for cancer—reducing pain and nausea and in increasing appetite—there are also several pre-clinical reports showing anti-tumor effects of CBD in cell culture and in animal models.xxviii These studies have found reduced cell viability, increased cancer cell death, decreased tumor growth, and inhibition of metastasis (reviewed in McAllister et al, 2015).xxix These effects may be due to the antioxidant and anti-inflammatory effects of CBD;xxx however these findings have not yet been explored in human patients. There are multiple industry sponsored clinical trials underway to begin to test the efficacy of CBD in human cancer patients.
Depending on your metabolism and what you’re hoping to improve, you may need a vastly different serving size than the next person to experience the positive effects of CBD. Serving sizes can vary dramatically, because there’s simply no one-size-fits-all CBD dosage.
Don’t order if you need it within a few weeks. Ordered 5 days ago and no word on when it will ship. Hoping to get a response to my email on Monday (a week after I ordered) but at the point it will take 2 weeks to get it- if I get it! Was excited to try this brand as I’ve heard great reviews. Unfortunately the slow shipping and no updates (in case something is wrong- I don’t see the vanilla even listed anymore) has left a pretty bad first impression.
Scientifically, industrial Hemp and Marijuana are the same plants, with a genus and species name of Cannabis Sativa. They have a drastically different genetic profile though. Industrial Hemp is always a strain of Cannabis sativa, while marijuana can be Cannabis sativa, Cannabis indica, or Cannabis ruderalis. The major difference is how industrial hemp has been bred compared to a marijuana form of Cannabis sativa. Typically speaking, industrial hemp is very fibrous, with long strong stalks, and barely has any flowering buds, while a marijuana strain of Cannabis sativa will be smaller, bushier, and full of flowering buds. However, newer industrial hemp varieties in the USA are being bred to have more flowers and higher yields of cannabinoids and terpenes, such as our Colorado hemp we’re now using!
“CBD-rich” versus “CBD dominant:” By “CBD-rich,” we mean a cannabis strain or product that has equal amounts of CBD and THC, or more CBD than THC (usually at least 4 percent CBD by dry weight.). By “CBD-dominant,” we mean strains or products that are CBD-rich but have very little THC content.
Recent research posted to Clinical Hemorheology and Microcirculation found that CBD may ease the inflammation in the pancreas in type 1 diabetes. This may be the first step in finding a CBD-based treatment for type 1 diabetes.
One key area of CBD research is epilepsy. Several scientists are focusing on its potential to reduce seizures, especially among those for whom other treatments have failed. “We’ve found significant positive effects with CBD,” says New York University neurologist Orrin Devinsky, who studies the compound for severe childhood epilepsy.
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This breakthrough is one of the most exciting discoveries in the field of epileptic seizures. A survey conducted with parents of children who have epilepsy reported jaw-dropping results. 84% of parents reported seeing fewer seizures in their children. In fact, the children also experienced better alertness, better moods, and improved sleep quality.
The United States Food and Drug Administration (FDA) has not approved CBD for the treatment of any condition. It can be difficult to know whether a product contains a safe or effective level of CBD or whether the product has the properties and contents stated on its packaging and marketing.
Hemp oil is fabricated from the plant called hemp. In other words, it is a hemp extract taken from the seeds of the plant. While this type of oil can be extracted from all plants in the cannabis genus, industrial hemp is the only plant used for hemp oil. This type of hemp is specifically produced industrially and the amount of psychoactive substances that are contained in it is minimal.
As her care taker, I would recommend that you take the edibles in small doses (or a dosage your comfortable with), rather than putting a cream on your skin. You really need to address Psoraisis internally first, then if you need to add cream. I can almost gaurantee you won’t need the creams. Just find yourself a good reputable dispensary to work with…hope this helps you, Jo
Cheng, D., Spiro, A. S., Jenner, A. M., Garner, B., & Karl, T. (2014). Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer’s disease transgenic mice [Abstract]. Journal of Alzheimer’s Disease, 42(4), 1,383-1,396. Retrieved from www.ncbi.nlm.nih.gov/pubmed/25024347
Jackson Leyden had always been a healthy kid; he practiced taekwondo, and he played lacrosse and baseball. But in 2011, a few months after his eighth birthday, he began having seizures several times a day. Many were brief, a half-minute of staring into space, but he also had severe episodes in which he would collapse, sometimes injuring himself. Over the next two years, he was hospitalized about 50 times, and he missed much of fourth and fifth grade.
We’ve systematically sought out the most beautiful and healthy hemp cultivars for our raw ingredients used in manufacturing, and we always test for purity and potency. Hemp, because of its innate ability to thrive easily, doesn’t require pesticides (the aromatic terpene compounds in hemp can actually act as natural pesticides), fertilizers, or herbicides in its cultivation, and requires much less water than standard commercial farming. The hemp we use is grown under the same methods and standards of organic farming.
The law as written requires physicians to “prescribe” CBD, which would break federal law. States with legal programs allow doctors to “recommend” as opposed to prescribe. However, the Texas Compassionate Use Program says that “prescription” is defined as “an entry in the compassionate-use registry” and three dispensing organizations had been licensed as of Dec. 15, 2017.
What makes CBD especially appealing is that it doesn’t get the user high. Most recreational marijuana users want this effect, of course, but many patients would rather avoid it. This has allowed CBD to sidestep many of the political, legal and medical concerns that have hindered the spread of medical marijuana.
This is a critical area for new research. While there is preliminary evidence that CBD may have therapeutic value for a number of conditions, we need to be careful to not get ahead of the evidence. Ninety-five percent of drugs that move from promising preclinical findings to clinical research do not make it to market. The recently announced elimination of the PHS review of non-federally funded research protocols involving marijuana is an important first step to enhance conducting research on marijuana and its components such as CBD. Still, it is important to try to understand the reasons for the lack of well-controlled clinical trials of CBD including: the regulatory requirements associated with doing research with Schedule I substances, including a requirement to demonstrate institutional review board approval; and the lack of CBD that has been produced under the guidance of Current Good Manufacturing Processes (cGMP) – required for testing in human clinical trials – available for researchers. Furthermore, the opportunity to gather important information on clinical outcomes through practical (non-randomized) trials for patients using CBD products available in state marijuana dispensaries is complicated by the variable quality and purity of CBD from these sources.
A CNN program that featured Charlotte’s Web cannabis in 2013 brought increased attention to the use of CBD in the treatment of seizure disorders. Since then, 16 states have passed laws to allow for the use of CBD products (not exceeding a specified concentration of THC) for the treatment of certain medical conditions. This is in addition to the 30 states that have passed comprehensive medical cannabis laws, which allow for the use of cannabis products with no restrictions on THC content. Of these 30 states, eight have legalized the use and sale of cannabis products without requirement for a doctor’s recommendation.
CBD primarily interacts with the body’s endocannabinoid system, a grouping of millions of cannabinoid receptors found throughout your body, but are primarily clustered in the brain and central nervous system. While CBD is a phytocannabinoid, or plant-based cannabinoid, your body also naturally produces cannabinoids, known as endocannabinoids. Almost every organ of your body, including your skin and digestive tract, contains cannabinoid receptors. The endocannabinoid system has four primary purposes including neuroprotection, stress relief, immune response, and regulating the body’s general state of balance, impacting faculties such as appetite, sleep, mood, and pain.
According to the Georgia Department of Public Health, “The new law does not address how low THC oil is made, purchased or shipped. The law only creates a procedure to ensure qualified persons will be protected from prosecution for having it in their possession.”
Because the extraction used to make our CBD oils yields a full spectrum extract, our hemp extracts contain over 80 different phyto-cannabinoids, including CBC, CBG, CBG-A, CBC-A, CBN and many others (and yes, our Hemp Classic product happens to naturally contain high levels of cannabidiol (CBD) because it’s made from a full spectrum hemp extract). In addition to the cannabinoids naturally present in our industrial hemp extracts, there are also many other types of natural molecules such as amino acids, carbohydrates, vitamins (including B1, B2, B6, D), fatty acids (including omega 3 & 6), trace minerals (including iron, zinc, calcium, magnesium, potassium), beta-carotene, chlorophyll, flavonoids, ketones, nitrogenous compounds, alkanes, glycosides, pigments, water, and terpenes. The most common terpenes in our hemp cannabis oil are Myrcene, Beta-caryophyllene, Terpinolene, Linalool, alpha-Pinene, beta-Pinene, Nerolidol og Phytol, trans-alpha-Bergamotene, Limonene/ beta-Phellandrene (Co-elution), and alpha-Humulene.
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