To understand “ What is CBD ” one need to understand where it comes from: CBD, like THC, is one of about 85 different Cannabinoids found in the Cannabis plant. And like THC, CBD is a cannabinoid. Cannabidiol or CBD is
Cannabinoids are agonists that bind themselves to specific receptors in the human body called cannabinoid receptors. Specific receptors are found throughout the body with the bulk of them located in the nervous system, but receptors can be found in just about every organ of the body. Cannabinoid receptors can be found in your skin, digestive tract and even in the sexual organs. The cannabinoid agonists interact with the cannabinoid receptors, a little bit like how a key can activate a lock. This interaction makes up the larger endocannabinoid system (ECS). The ECS is a big network of receptor proteins which all have different functions. It has been said the ECS is the most significant neurotransmitter system in the human body. The ECS helps with man bodily function, such as:
Some studies show that CBD can counteract these adverse effects, but more research is needed, as most of this research is done on animals or is based on anecdotal reports. Little research has focused on the safety and side effects of CBD in humans; however, clinical trials indicate that only a few, generally mild side effects have been observed after CBD administration and tolerance for CBD does not seem to occur.
CBD (Cannabidiol) is a prominent, non-psychoactive cannabinoid found in hemp. It is generally extracted from hemp plants that are naturally high in CBD and other phytochemicals. There are over 80 different cannabinoids found in hemp. It is commonly used for its therapeutic properties.
Jump up ^ Fournier G, Beherec O, Bertucelli S (2003). “Intérêt du rapport Δ-9-THC / CBD dans le contrôle des cultures de chanvre industriel” [The advantage of the Δ-9-THC / CBD ratio in the control of industrial hemp crops]. Annales de Toxicologie Analytique (in French). 15 (4): 250–259. doi:10.1051/ata/2003003.
Cannabis-genus include 3 distinct species, i.e. Cannabis Savita, Cannabis Indica, and Cannabis Ruderalis. Sativa is the most common strain of cannabis. Cultivated throughout history for a number of purposes, it is used for the production of seed oil, food, hemp fibre, and even recreation.
Yamaori S, Ebisawa J, Okushima Y, et al. Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. Life Sci 2011;88(15-16):730-6. View abstract.
There is an ever-changing number of states that do not necessarily consider marijuana to be legal but have laws directly related to CBD oil. This information is up to date as of July 24, 2017, but the laws frequently change.
The law as written requires physicians to “prescribe” CBD, which would break federal law. States with legal programs allow doctors to “recommend” as opposed to prescribe. However, the Texas Compassionate Use Program says that “prescription” is defined as “an entry in the compassionate-use registry” and three dispensing organizations had been licensed as of Dec. 15, 2017.
We do sell pure, isolated cannabidiol in crystalline form. It is not fit for human consumption and is for research purposes only. This CBD isolate is somewhere between 96% and 99.9% pure. While all the Certificates of Analysis (COAs) for our CBD Isolate reveal cannabidiol levels at 90%-100%, we are almost completely certain that every batch of our CBD Isolate extract has been more than 99% pure. The deviation in results is due to instances of unreliable third-party testing.
Whenever you start a treatment, regardless of its kind, you should be interested in the interactions that may occur between your treatment and other drugs you may take or could take in the future. Some drugs just don’t go well……Read More »
THC, being the first phytocannabinoid discovered, has been much more extensively researched than CBD. THC is strongly psychoactive and because of its ability to alter your behaviour and lose control of what you do it is a popular illegal drug. However, having been shown to be effective as a moderate-strength analgesic, THC has desirable medical applications. It is also a mild pain relief medicine, and can effectively treat symptoms of “serious” diseases such as AIDS and cancer. THC have therefore been legalized for medical purposes. Medical marijuana is safe when prescribed by a doctor and can improve the quality of life for many people suffering from serious and/or chronic diseases.
I finally got oil a month ago after dealing with chronic nerve pain/migraines, massive anxiety, and getting off of prescription opiates. I’m so so sad I didn’t do this before but I’m grateful I take it now.
On May 4, 2016, Gov. Bentley signed HB 61 into law. Known as Leni’s Law, the bill provides an affirmative defense for possession of CBD oil “for specified debilitating conditions that produce seizures.”
Various breeds/strains of “medical marijuana” are found to have a significant variation in the ratios of CBD-to-THC and are known to contain other non-psychotropic cannabinoids. However it is only the amount of ∆9-THC that chemically gives a legal determination as to whether the plant material(s) used for the purposes of extracting CBD are considered hemp, or considered marijuana.
“That’s really the only area where the evidence has risen to the point where the FDA has said this is acceptable to approve a new drug,” said Timothy Welty, chair of the department of clinical sciences at Drake University’s College of Pharmacy and Health Sciences, in Des Moines, Iowa.
CBD hemp oil is derived from certain Cannabis varieties known as Hemp. Representing 40% of all Cannabis extracts, it is the second most abundant of 85 chemicals known as Cannabinoids, that are all present in Cannabis plants. Unfortunately, however, the most intoxicating part of Cannabis known as THC, which is responsible for the so-called “high” that brought about its popularity among Marijuana users, is also the most abundant
“The endocannabinoid system (ECS) is a group of endogenous cannabinoid receptors located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors.” Wikipedia
Iuvone, T., Esposito, G., Esposito, R., Santamaria, R., Di Rosa, M., and Izzo, A. A. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem. 2004;89(1):134-141. View abstract.
Jump up ^ Pertwee RG (January 2008). “The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin”. British Journal of Pharmacology. 153 (2): 199–215. doi:10.1038/sj.bjp.0707442. PMC 2219532 . PMID 17828291.
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Although it’s a relatively new product in the CBD hemp oil industry, CBD isolate extraction and CBD isolate ingestion is taking the cannabinoid market by storm, becoming increasingly popular with retail customers, formulators, and wholesalers alike. Its many uses and applications in this unmodified form are almost endless and its versatility unparalleled. Plus, you are put in complete control of exactly how much CBD goes into each serving but not matter how much you use it will not get you high.
Jump up ^ Aizpurua-Olaizola O, Soydaner U, Öztürk E, Schibano D, Simsir Y, Navarro P, Etxebarria N, Usobiaga A (February 2016). “Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes”. Journal of Natural Products. 79 (2): 324–31. doi:10.1021/acs.jnatprod.5b00949. PMID 26836472.
^ Jump up to: a b c d Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M (July 2017). “Cannabidiol: State of the art and new challenges for therapeutic applications”. Pharmacol. Ther. 175: 133–150. doi:10.1016/j.pharmthera.2017.02.041. PMID 28232276.
Just like THC, CBD is a chemical compound extracted from hemp plants. Both hemp and cannabis contain cannabidiol (CBD), the non-psychoactive substance. THC, however, is the substance that gives users that “high” or psychoactive effect. CBD has many similarities to THC when it comes to potential health benefits, but the main difference is that it’s a non-psychoactive substance, so it doesn’t give a natural high to users. It also does not cause anxiety, paranoia, or the mouth and eye dryness associated with THC, even when CBD is consumed in higher concentrations. Due to these inherent advantages, most high-quality CBD oil products on the market today are extracted from the hemp plant. THC oil, on the other hand, is derived from the cannabis plant, so it contains high levels of THC and low levels of CBD. On the other hand, industrially produced hemp contains higher concentrations of CBD with only trace amounts of THC, so it’s safer and offers fewer symptoms for users.
Studies have started to lead researchers to believe that CBD’s ability to act on the endocannabinoid system and other neuro systems in the brain, may lead to giving people neurological disorders some help. In recent time medical journals have started to publish papers involving the use of CBD and neurological disorders like epilepsy and multiple sclerosis. Albeit research in this field is in its infancy the results from several studies do look promising. One study gave 214 people who have severe epilepsy 0.9 to 2.3 grams of Cannabidiol per pound of body weight. The results were quite remarkable with a reduction in seizures by a median of 36.5%. Another study showed children with Dravet Syndrome (a complex childhood epilepsy disorder) saw reduced seizure activity compared to the placebo group. Another area where CBD is showing promising results in helping a specific group of neurological disorder is in the field of Parkinson’s disease. Several studies have shown Cannabidiol may help with sleep quality for people suffering from Parkinson’s Disease.
Live in iowa and broke my back 3 yrs ago tired of the pain pills and found hemp oil now I read about that cbd oil is way different than hemp oil. Help??? What do I need for pain does the hemp oil work or do I need the other where can I get what I need without going to the local headshop
Hey Matthew! Thanks for reaching out and asking. It depends on a lot of things, you would have to ask around to some CBD drink companies to find out more! Sorry I can’t be of more help, but good luck in your search 🙂
If you wanted to research the pros and cons of taking CBD vs THC (Cannabis oil), and the difference between the two, this article is for you. We’ll also conclude with what might be the most important reason why you want to choose CBD instead of THC for the health benefits, and the best place to purchase them – here at American Hemp Oil.
Tetrahydrocannabinol (THC) is the main psychoactive cannabinoid found in cannabis, and causes the sensation of getting “high” that’s often associated with marijuana. However, unlike THC, CBD is not psychoactive.
Rosenberg, Tsien, Whalley, and Devinsky (2015) have recently reviewed the role of cannabinoids in epilepsy; highlighting proconvulsive effects (e.g., THC) and anticonvulsive effects (e.g., cannabidiol). The mechanisms of action of cannabidiol in epilepsy have also been recently reviewed (Reddy & Golub, 2016). Much work with SCB in epilepsy has focused on WIN55,212-2. WIN55,212-22 potentiated the effects of four antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, and valproate) in mice (Luszczki et al., 2011). However, the authors also caution that impairment of motor coordination, long-term memory, and a reduction of skeletal muscular strength was also seen with these combination treatments. The same group found WIN 55,212-2 in combination with lamotrigine, pregabalin, and topiramate and second- and third-generation anticonvulsants gabapentin, levetiracetam but not lacosamide, oxcarbazepine, pregabalin, and tiagabine to potentiate anticonvulsant effects in mice (Florek-Luszczki et al., 2015; Luszczki, Wlaz, Karwan, Florek-Luszczki, & Czuczwar, 2013).
On May 30, 2014, Iowa Governor Terry Branstad signed SF 2360 into law, saying “This bill received tremendous support and truly shows the power of people talking to their legislators and to their governor about important issues to them, to their families and to their children.”
CBD is safer than THC for a number of reasons. Certain studies found a link between THC and psychiatric conditions such as schizophrenia, depression, and psychosis. Note however, that this does not prove that THC definitely does cause these conditions.
Massi P, Valenti M, Vaccani A, et al. 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem 2008;104(4):1091-100. View abstract.
A muscle disorder called dystonia. Early research suggests that taking cannabidiol daily for 6 weeks might improve dystonia by 20% to 50% in some people. But higher quality research is needed to confirm this.
Jump up ^ Iffland K, Grotenhermen F (2017). “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies”. Cannabis Cannabinoid Res. 2 (1): 139–154. doi:10.1089/can.2016.0034. PMC 5569602 . PMID 28861514.
It is however difficult to distinguish between the clinically desirable and undesirable effects of phyto-cannabinoids, since cannabinoid receptors send a variety of signals that often interconnect to regulate body functions. CB1 receptors send signals that regulate senses, while cannabinoids that co-ordinated with CB2 receptors can at the same time affect responses from your gut ad also your nervous system.
CB2 receptors are found mostly in the immune system, and they seem to reduce inflammation and certain kinds of pain. Although cannabinoids all have similar structures, they display a wide array of actions at each of the different receptors.
Cheng, D., Spiro, A. S., Jenner, A. M., Garner, B., & Karl, T. (2014). Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer’s disease transgenic mice [Abstract]. Journal of Alzheimer’s Disease, 42(4), 1,383-1,396. Retrieved from www.ncbi.nlm.nih.gov/pubmed/25024347
Cannabidiol is POSSIBLY SAFE when taken by mouth and appropriately in adults. Cannabidiol doses of up to 300 mg daily have been used safely for up to 6 months. Higher doses of 1200-1500 mg daily have been used safely for up to 4 weeks. Cannabidiol sprays used under the tongue have been used in doses of 2.5 mg for up to 2 weeks.
CBD Oil Helena GA | Where To Purchase Near Me
About CBD Oil Helena GA | Where To Purchase In July, 2017
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